Spike may refer to:
- Spike (Dominia): vicious slug-like creatures that inhabit Rath
- Spike (Al Amarja): A bully on Al Amarja
- Spike (Crown of the Emperors): A member of the Democratic Union
- Spike (Pangea): A warrior of Scizornia
- Spike Dougan: A dim-witted gunslinger and member of the Blackjacks.